Table 1.

The design of the spray drying experiments.

Formulation a	Spray Solution Composition b [% w/w in Deionized Water]				Nominal Particle Composition [% w/w]
	Drug	Mannitol	Leucine	Ethanol	Drug	Mannitol	Leucine
M1L0E25	0.113	0.638	0.000	24.813	15.00	85.00	0.00
M2L1E25	0.113	0.425	0.212	24.813	15.00	56.70	28.31
M1L2E25	0.113	0.212	0.425	24.813	15.00	28.31	56.70
M0L1E25	0.113	0.000	0.638	24.813	15.00	0.00	85.00
M1L0E50	0.113	0.638	0.000	49.625	15.00	85.00	0.00
M2L1E50	0.113	0.425	0.212	49.625	15.00	56.70	28.31
M1L2E50	0.113	0.212	0.425	49.625	15.00	28.31	56.70
M0L1E50	0.113	0.000	0.638	49.625	15.00	0.00	85.00

^a Formulation codes are expressed in the form MxLyEz, where x:y w/w is the mannitol:leucine ratio and z% w/w is the concentration of ethanol in the spray solvent. ^b All spray solutions contained hydrochloric acid at a concentration of 0.01 mol/kg. For all formulations, the total solute concentration in the spray solution was 0.75% w/w and the nominal drug:total excipient ratio was 15:85 w/w.