Scheme 1.
Synthetic scheme followed to achieve hyaluronic acid–doxorubicin (HA-DOX) conjugates. (i) DMTMM Cl, water, 2 h, RT; DOX, water, 96 h. (ii) DMTMM Cl, water, 2 h, RT; hydrazine linker, water, 96 h. (iii) DOX, CH3COOH (pH = 5), water, 96 h.
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