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. 2022 Jan 13;9(1):27. doi: 10.3390/jcdd9010027

Figure 4.

Figure 4

In basal conditions, very low basal levels of soluble ICAM-1 and VCAM-1 were measured in the HUVEC supernatants. Stimulation with IL-6 increased significantly the supernatant concentrations: ICAM-1 ((A) 33.16 ± 2.75 ng/mL, * p < 0.001 vs. Control; one-way ANOVA with Tukey’s post hoc test) and VCAM-1 ((B) 25.83 ± 0.21 ng/mL, * p < 0.001 vs. Control; one-way ANOVA with Tukey’s post hoc test). VitD preincubation significantly prevented both soluble ICAM-1 ((A) 15.06 ± 0.7 ng/mL, ** p < 0.001 vs. IL-6-treated ECs; one-way ANOVA with Tukey’s post hoc test) and VCAM-1 levels ((B) 11.39 ± 0.62 ng/mL, ** p < 0.001 vs. IL-6-treated ECs; one-way ANOVA with Tukey’s post hoc test). Each column represents the mean ± SD of 6 different experiments.