. 2022 Jan 4;14(1):112. doi: 10.3390/pharmaceutics14010112

Table 6.

In vitro release assays at pH 7.8.

Variable		MA			GA			PE			STC			GA/STC			PE/STC
Variable		SIDI	PH	PH/CHL	SIDI	PH	PH/CHL	SIDI	PH	PH/CHL	SIDI	PH	PH/CHL	SIDI	PH	PH/CHL	SIDI	PH	PH/CHL
ST (min)		500.1	100.1	50.1	54.1	239.1	1229.1	1634.1	1514.1	1594.1	2160.1	2107.1	2160.1	1080.1	1080.1	1080.1	1900.1	1260	1944.1
ZO	F₀	76.984	28.249	38.031	66.060	43.196	38.309	39.624	52.759	40.692	14.169	16.400	7.122	27.114	44.0878	56.337	26.737	28.941	12.727
	K₀	0.031	0.412	0.461	0.250	0.190	0.178	0.036	0.023	0.037	0.034	0.037	0.036	0.059	0.046	0.035	0.033	0.035	0.046
	R²	0.827	0.956	0.663	0.475	0.835	0.980	0.910	0.838	0.880	0.961	0.910	0.947	0.913	0.709	0.508	0.952	0.887	0.930
	R²_Adj	0.816	0.952	0.642	0.451	0.826	0.979	0.907	0.834	0.975	0.959	0.907	0.945	0.910	0.697	0.489	0.951	0.882	0.927
FO	K₁	0.010	0.023	0.028	0.097	0.012	0.0009	0.003	0.030	0.003	0.001	0.001	0.0004	0.003	0.007	0.009	0.001	0.003	0.0008
	K_max	97.320	77.731	99.845	94.204	97.688	371.43	87.869	77.297	93.081	126.21	120.03	156.62	90.655	86.158	89.574	94.589	71.232	124.290
	R²	0.502	0.813	0.962	0.874	0.935	0.982	0.887	0.580	0.940	0.986	0.964	0.982	0.957	0.936	0.965	0.961	0.850	0.984
	R²_Adj	0.470	0.797	0.959	0.869	0.931	0.982	0.882	0.569	0.937	0.986	0.963	0.982	0.956	0.933	0.964	0.960	0.844	0.983
HG	K_H	4.141	7.076	8.859	10.234	6.069	6.759	2.521	2.475	2.564	1.799	1.922	1.740	2.762	3. 101	3.201	2.022	2.078	2.108
	R²	0.865	0.912	0.837	0.699	0.944	0.967	0.989	0.903	0.977	0.963	0.934	0.950	0.977	0.862	0.700	0.978	0.933	0.956
	R²_Adj	0.865	0.912	0.837	0.699	0.944	0.967	0.989	0.903	0.977	0.963	0.934	0.950	0.977	0.862	0.700	0.978	0.933	0.956
HC	K_HC	0.0017	0.0036	0.0076	0.0093	0.003	0.0016	0.0005	0.0007	0.0006	0.0002	0.0003	0.0002	0.0006	0.001	0.012	0.0003	0.0003	0.0003
	R²	0.802	0.919	0.969	0.875	0.971	0.791	0.9562	0.779	0.976	0.986	0.968	0.984	0.958	0.919	0.877	0.982	0.904	0.987
	R²_Adj	0.802	0.919	0.969	0.875	0.971	0.791	0.9562	0.779	0.976	0.986	0.968	0.984	0.958	0.919	0.877	0.982	0.904	0.987
KrP	K_kp	71.286	14.051	16.452	46.261	15.323	2.331	11.684	30.156	9.538	0.485	0.605	0.211	4.119	14.235	23.560	2.416	5.371	0.613
	N	0.043	0.343	0.367	0.157	0.323	0.657	0.279	0.141	0.312	0.676	0.658	0.781	0.440	0.267	0.198	0.475	0.361	0.671
	R²	0.508	0.857	0.868	0.827	0.912	0.985	0.976	0.899	0.964	0.980	0.944	0.966	0.978	0.910	0.809	0.975	0.919	0.964
	R²_Adj	0.477	0.845	0.860	0.819	0.907	0.984	0.975	0.897	0.962	0.979	0.942	0.965	0.977	0.906	0.809	0.974	0.915	0.962
DTM		C-I	C-I	C-I	C-I	C-I	ANM	C-I	C-I	C-I	ANM	ANM	ANM	ANM	C-I	C-I	ANM	C-I	ANM

SIDI, enriched fraction of SI used in all formulated samples; PH, phytosome; PH/CHL, cholesterol-incorporated phytosome; GA, gum Arabic; MA, maltodextrin; PE, pectin; STC, starch; min; minutes; ZO, zero-order; FO, first-order; KrP, Korsmeyer–peppas; HG, Higuchi; HC, Hixson–Crowell; ST, stabilization time (approximately the time when the release start to be stable and the curve change to be linear); R²_Adj, R²_Adjusted; DTM, drug transport mechanism; C-I, case-I; ANM, anomalous; C-II, case-II transport; SC-II, super case-II.