. 2022 Jan 16;12(1):83. doi: 10.3390/metabo12010083

Table 2.

Effect of the intracerebroventricular injection of taurine or CRF on amino acid concentrations in the brainstem of chicks exposed to social isolation stress.

Free Amino Acids	Saline			Taurine			CRF			Taurine + CRF			p Value
Free Amino Acids	Saline			Taurine			CRF			Taurine + CRF			Taurine	CRF	Taurine × CRF
Essential amino acids
Isoleucine	93	±	4	89	±	2	95	±	2	84	±	4	p < 0.05	NS	NS
Phenylalanine	88	±	4	84	±	6	95	±	6	75	±	2	p < 0.05	NS	NS
Glycine	2814	±	66	2955	±	62	2953	±	63	3067	±	44	p < 0.05	p < 0.05	NS
Nonessential amino acids
Taurine	2686	±	66 ^b	3903	±	253 ^a	2982	±	127 ^b	3168	±	90 ^b	p < 0.0005	NS	p < 0.005
Tyrosine	86	±	5 ^ab	88	±	4 ^ab	107	±	8 ^a	81	±	4 ^b	p < 0.05	NS	p < 0.05
Cysteine	100	±	5	88	±	4	93	±	5	86	±	5	p < 0.05	NS	NS

The number of chicks used in each group was 7−9. Values are means ± SEM in pmol/mg wet tissue. Different superscripts in the same row indicate significant differences (p < 0.05) between saline, taurine, CRF and CRF + taurine groups. NS, not significant; CRF, corticotropin-releasing factor.