Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Scheme showing folic acid- and FR-targeted formulations internalization. Folic acid or another ligand binds to folate receptor (A). An invagination of the plasma membrane is generated (B) and the folate receptor-ligand conjugate is enclosed in a vesicle named endosome (C), where the acidic pH triggers conformational changes in the folate receptors, inducing the release of the ligand (D) and the drug into the cells, and the recycling of the folate receptor to the cell surface (E,F).
