Table 1.
Diagnostic studies and results during hospital admission.
| Laboratory Studies | Source | Result (Normal Range) |
|---|---|---|
| Infectious Disease | ||
| SARS-CoV2 PCR | NP swab | Negative |
| Anti-SARS-CoV2 nucleocapsid antibodies | Blood | Negative |
| Culture and gram stain | CSF | Negative |
| Adenovirus PCR | Blood, NP swab | Negative |
| Enterovirus PCR | Blood, CSF | Negative |
| Herpes Simplex Virus type 1 and type 2 | CSF | Negative |
| Varicella Zoster Virus PCR | CSF | Negative |
| Epstein Barr Virus PCR | Blood | Negative |
| Coxsackie A9 antibodies | Blood | Negative |
| Ehrlichia and Anaplasma PCR | Blood | Negative |
| Rickettsia rickettsia serologies, IgM, IgG | Blood | Negative |
| Eastern Equine Encephalitis IgM | Blood | Negative |
| West Nile Virus IgM | Blood | Negative |
| Pneumococcus IgG | Blood | Negative |
| Tetanus IgG | Blood | Negative |
| RVP (Adenovirus PCR, hMPV PCR, Rhinovirus PCR, Influenza A and B PCR, RSV PCR) | NP swab | Negative |
| Legionella antigen | Urine | Negative |
| Lyme antibody index | CSF | Negative |
| Neurologic | ||
| Anti-MOG antibodies | Blood, CSF | Negative |
| Autoimmune encephalitis panel | Blood, CSF | Negative |
| CNS demyelinating disease panel # | Blood | Negative |
| Cardiac | ||
| Viral Respiratory Panel (Myocarditis) | NP Swab | Negative |
| Electrocardiogram (ECG) | N/A | Widespread repolarization abnormalities, with nonspecific ST-T wave changes |
| Echocardiogram | N/A | Normal systolic and diastolic ventricular function, normal coronary dimensions, no significant valvar dysfunction, and no pericardial effusion |
| Cardiac MRI | N/A | No evidence of active myocarditis or late gadolinium enhancement |
| Immunology * | ||
| Soluble CD25, units/mL | Blood | 690 (137–838) |
| Serum inflammatory markers ^,* | ||
| D-dimer, mcg/mL FEU | Blood | 0.43 |
| Erythrocyte sedimentation rate, mm/h | Blood | 5 |
| Platelet count, K cells/μL | Blood | 313 |
| Other * | ||
| White blood, cells/mm3 | CSF | 2 with 7% neutrophils, 35% lymphocytes, 58% macrophages |
| Red blood cells | CSF | 0 |
| Protein, mg/dL | CSF | 14.9 |
| Glucose, mg/dL | CSF | 85 |
| Opening pressure, cmH2O | CSF | 21 |
| Prothrombin time, seconds | Blood | 15.7 (12.1–14.6) |
| AST, unit/L | Blood | 24 (2–40) |
| ALT, unit/L | Blood | 35 (3–30) |
Abbreviations: SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; NP, nasopharyngeal; CSF, cerebrospinal fluid; PCR, polymerase chain reaction; RVP, respiratory viral panel; hMPV, human metapneumovirus; RSV, respiratory syncytial virus; MOG, myelin oligodendrocyte glycoprotein; N/A, not applicable. # Includes antibodies to NMO/AQP4 (Neuromyelitis Optica/aquaporin-4) and MOG, sent 3 weeks after hospital discharge. * Maximum values during hospital admission. ^ Serum levels of procalcitonin, ferritin, lactate dehydrogenase, fibrinogen and IL6 and CSF IL-6 and IL-10 were not measured.