Table 1.
Summary of source organisms, biological/pharmacological activities, compound numbers, and the cited references.
| Organisms | Biological/Pharmacological Activities | Compound | Reference |
|---|---|---|---|
| 1. Marine-derived fungi | |||
| Antibacterial activity | |||
| Aspergillus sp. YJ191021 |
Xanthomonas oryzae pv. oryzae
X. oryzae pv. Oryzicola Edwardsiella tarda Vibrio anguillarum V. parahaemolyticus Aeromonas hydrophilia |
41 | [22] |
| A. fumigatus SCSIO 41012 |
Acinetoobacter baumannii ATCC 19606, A. baumannii ATCC 15122, Klebsiella pneumoniae ATCC 14578 Staphylococcus aureus ATCC 16339 |
93 | [41] |
| Antibiofilm activity | |||
| Eurotium chevalieri KUFA 0006 | S. aureus ATCC 25923 | 9 | [14] |
| Anti-Quorum sensing activity | |||
| Aspergillus sp. HNMF114 | Chromobacterium violaceum CV026 | 91, 92 | [40] |
| Antifungal activity | |||
| Aspergillus sp. YJ191021 | Rhizoctonia solani | 45 | [22] |
| A. fumigatus SCSIO 41012 |
Fusarium oxysporum f. sp. cucumerinum F. oxysporum f. sp. momordicae |
93 | [41] |
| Penicillium chrysogenum V11 |
Colletotrichum gloeosporioides
R. solani |
82, 83 | [34,35] |
| Antiviral activity | |||
| Fusarium sp. L1 | Anti-Zika virus | 48, 49, 74, 75 | [7] |
| A. candidus HDN15-152 | Anti-influenza A virus (H1N1) | 65 | [27] |
| P. raistrickii IMB17-034 | Anti-hepatitis C virus | 90 | [39] |
| Scedosporium apiospermum F41 | Anti-hepatitis C virus | 106, 114 | [12] |
| Anticancer activity | |||
| Aspergillus sp. KMM4676 | 22Rv1, PC-3, and LNCaP | 66, 67 | [28] |
| A. candidus KUFA0062 | Hep G2, HT29, HCT116, A549, A375, MCF7 and U251 | 80 | [33] |
| P. chrysogenum V11 | MDA-MB-435, SGC-7901,A549 | 81, 83 | [34,35] |
| Anti-inflammatory activity | |||
| Aspergillus versicolor | iNOS inhibitory activity | 17, 18, 35, 36, | [18] |
| Aspergillus sp. YJ191021 | Inhibit secretion of 1L-1β by THP-1 cells | 41, 45, 46 | [22] |
| Antidiabetic activity | |||
| S. apiospermum F41-1 | promote triglyceride accumulation in 3T3-L1 | 6 | [12] |
| Penicillium sp. KFD28 | Inhibition of protein tyrosine | 50, 51, 54, | [24] |
| Aspergillus sp. SF-5280 | phosphatases (PTPs) | 55, 57 | [25] |
| Inhibition of non-transmembrane PTPs (PTP1B) | 116 | [43] | |
| Neuroprotective activity | |||
| P. dimorphosporum KMM 4689 | increased a viability of paraquat-treated cells | 27, 29 | [30] |
| Pro-angiogenic activity | |||
| A. austroafricanus Y32-2 | Pro-angiogenic activity in a vatalanib (PTK787)-induced vascular injury zebrafish model | 73 | [30] |
| 2. Marine-derived bacteria | |||
| Antibacterial activity | |||
| Streptomyces sp. SCSIO 11791 | Micrococcus luteus ML01, S. aureus ATCC 29213, and a panel of MRSA isolated from human patients (MRSA 991, MRSA 1862, MRSA 669 A, MRSA A2) and pig (MRSA GDQ6P012P, MRSA GDE4P037P) | 119, 120 | [46] |
| Acinetobacter sp. ZZ1275 | S. aureus (MRSA), E. coli | 118, 121 | [45] |
| E. coli transfected by metagenomic DNA prepared from the marine sponge Dicderma calyx | Bacillus cereus, S. aureus (MSSA) | 122 | [47] |
| Antifungal activity | |||
| Acinetobacter sp. ZZ1275 | Candida albicans | 118, 121 | [45] |
| Anticancer activity | |||
| Streptomyces sp. SCSIO 11791 | MDA-MB-435, MDA-MB-231 NCI-H460, HCT-116, HepG2. MCF10A | 119, 120 | [46] |
| 3. Marine sponges | |||
| Antibacterial activity | |||
| Spongosorites sp. | Mycobacterium tuberculosis CDC1551 | 141 | [52] |
| Spongosorites sp. | S. aureus | 156–158, 159 | [59] |
| S. entérica | 158, 159 | [59] | |
| Topsentia sp. | S. aureus ATCC 29213 | 143, 161 | [54] |
| Callyspongia siphonella | S. aureus and B. subtilis | 162, 163, | [60] |
| Myrmekioderma sp. | E. coli and B. subtilis | 164 | [67] |
| Antiviral activity | |||
| Topsentia sp. | Anti-HIV activity | 143, 161 | [54] |
| Anticancer activity | |||
| Fascaplysinopsis reticulata | HeLa | 133a, 133b | [50] |
| Spongosorites sp. | Human pancreatic cell lines: PANC-1, MIA PaCa-2, BxPC-3, ASPC-1 | 141 | [52] |
| Dragmacidon sp. | A549, HT29, and MDA-MB-231 | 153, 154 | [58] |
| Spongosorites sp. | A549 and K562 | 155–158 | [59] |
| Anti-inflammatory activity | |||
| Geodia barretti | Decrease dendritic cell secretion of pro-inflammatory cytokine IL-12p40 and anti-inflammatory cytokine IL-10 production | 139, 140 | [59] |
| Antidiabetic activity | |||
| Psammocinia vermis | Increase adiponectin secretion during adipogenesis in hBM-MSCs | 123–125 | [48] |
| Fascaplysinopsis reticulata | inhibitory activity against PTP1B | 132a, 132b | [50] |
| Antiparasitic activity | |||
| Callyspongia siphonella | Antitrypanosomal activity against Trypanosoma brucei | 162, 163 | [60] |
| Enzyme inhibitors | |||
| Guitarra fimbriata | Inhibitor of alkaline phosphatase | 128 | [49] |
| Spongosorites sp. | Inhibit sortase A | 156, 157, 159, 160 | [59] |
| 4. Bryozoans | |||
| Anticancer activity | |||
| Securiflustra securifrons | A2058, HT-29, MCF-7, MRC-5 | 179, 180 | [64] |
| Anti-inflammatory activity | |||
| Flustra foliácea | Decrease DC secretion of the pro-inflammatory cytokine IL-12p40 | 166, 168, 170, 178 | [63] |
| 5. Algae | |||
| Antibacterial activity | |||
| Laurencia similis | S. aureus, B. subtilis, B. thuringensis, Pseudomonas lachrymans, Agrobacterium tumefaciens, Xanthomonas vesicatória, Ralstonia solanacearum | 182, 183 | [65] |