Table 3.

Cytokine comparison from T0 to T1 and from both timepoints compared to HV. Concentrations are expressed in pg/mL.

Patients (n = 41)			Patients (n = 41)			HV (n = 15)
Cytokines at T0	Median (Range)	p-Value vs. T1	Cytokines at T1	Median (Range)	p-Value vs. HV	Cytokines HV	Median (Range)	p-Value vs. T0
IL-2	0.27 (0.00–3.17)	0.0004	IL-2	0.43 (0.00–12.90)	ns	IL-2	0.40 (0.00–0.80)	ns
IL-4	0.07 (0.00–2.82)	0.0001	IL-4	0.53 (0.00–1.97)	0.0003	IL-4	0.15 (0.08–0.68)	0.0045
IL-5	0.31 (0.00–20.2)	ns	IL-5	0.46 (0.06–14.60)	ns	IL-5	0.56 (0.04–5.24)	ns
IL-6	6.52 (0.82–212.4)	ns	IL-6	7.73 (1.15–216.1)	0.0001	IL-6	0.36 (0.00–3.70)	0.0001
IL-8	15.09 (0.57–542.4)	ns	IL-8	14.95 (3.17–240.6)	0.0001	IL-8	3.31 (2.02–5.76)	0.0001
IL-10	2.61 (0.37–28.7)	ns	IL-10	3.52 (0.16–49.26)	0.0001	IL-10	1.68 (0.90–2.56)	0.0062
IL-12	1.55 (0.0–3.17)	ns	IL-12	1.32 (0.00–2.35)	ns	IL-12	1.47 (0.47–70.36)	ns
Il-13	0.34 (0.00–1063)	0.0001	IL-13	6.17 (0.00–916)	ns	IL-13	8.14 (2.36–74.36)	0.0001
IL-15	3.23 (0.27–16.80)	ns	IL-15	3.27 (1.44–11.00)	ns	IL-15	3.10 (0.65–15.45)	ns
IL-21	32.53 (0.0–973.5)	ns	IL-21	22.04 (0.0–742.7)	0.0018	IL-21	0.00 (0.00–143.5)	0.0008
TGF-β	204.8 (86.55–915.9)	ns	TGF-β	233.9 (54.09–1255)	0.0001	TGF-β	90.24 (31.33–160.2)	0.0001
TNF-α	0.43 (0.0–737.7)	ns	TNF-α	2.65 (0.00–879.8)	ns	TNF-α	8.24 (2.50–50.00)	ns
VEGF	495.2 (224.9–1503)	0.0045	VEGF	523.7 (220.7–1248)	0.0001	VEGF	30.70 (9.80–186.3)	0.0001
IFN-γ	0.91 (0.03–7.79)	ns	IFN-γ	1.04 (0.20–10.40)	0.0039	IFN-γ	0.12 (0.00–2.10)	0.0091
CCL-2	231.4 (56.08–995.2)	ns	CCL-2	225.5 (74.09–878.1)	0.0001	CCL-2	44.72 (18.49–187.0)	0.0001
CCL-4	61.50 (0.00–125.8)	ns	CCL-4	62.73 (20.56–166.3)	0.0002	CCL-4	30.67 (4.27–67.20)	0.0003
CCL-22	497.4 (56.08–2727)	ns	CCL-22	476.2 (115.4–2173)	ns	CCL-22	347.2 (100.2–819.0)	ns
CXCL-10	210.1 (12.98–1039)	ns	CXCL-10	229.3 (82.88–1282)	0.0001	CXCL-10	71.70 (49.65–128.0)	0.0001

CCL, C-C motif ligand; IL, interleukin; ns, not significant.