Table 4.
Mutations in 23S rRNA and rpl22 that were associated with CAM-resistance.
| Gene | Strain | Sensitive (n = 5) | MMM3 | MMM43 | MMM86 | MMM131 | MMM149 |
|---|---|---|---|---|---|---|---|
| MIC (mg/L) | 0.38 | 16 | 8 | 128 | 64 | ||
| 23S rRNA | Position | ||||||
| 64 | G/A | ||||||
| 186 | T/C | ||||||
| 228 | G/A | ||||||
| 242 | T-Del | ||||||
| 243 | T-Del | ||||||
| 247 | A-Ins | ||||||
| 248 | T/C | T/C | T/C | ||||
| 425 | A/G | ||||||
| 513 | C/T | ||||||
| 559 | C/T | ||||||
| 763 | A/G | ||||||
| 822 | G/A | ||||||
| 1286 | A/G | ||||||
| 1312 | C/T | ||||||
| 2219 | C/T | ||||||
| 2937 | G/A | ||||||
| rpl22 | 16 | T/C | |||||
| 20 | G/A | ||||||
| 69 | T/C | T/C | |||||
| 125 | C/T | ||||||
| 135 | G/A | ||||||
| 147 | G/T | ||||||
| 237 | GCG-Ins | C/T | |||||
| 267 | A/G |
A: Alanine, C: Cysteine, G: Glycine, T: Threonine, Del: Deletion, Ins: Insertion, MMM: bacteria strain.