Figure 4.

Treg depletion decreases suppressive signaling and allows for T cell activation and latency reactivation. Through the production of various cytokines and immune checkpoints, Tregs suppress other immune cells towards the resting state. By depleting Tregs with various agents, e.g., IL-2-diphtheria toxin or αCCR4, this should allow for activation of T cells to occur and thereby reactivate latent virus as well as bolster reservoir clearance by no longer impeding the cell-mediated immune responses.