Table 4.
Summary of findings—effects of awake prone positioning on predefined outcomes. RR: relative risk; CI: confidence interval; SoC: standard of care; APP: awake prone positioning; HFNC: high-flow nasal cannula.
| Outcome | Results | Absolute Effect Estimates | Certainty of Evidence | |
|---|---|---|---|---|
| SoC | APP | |||
| All-cause mortality (28 days) | RR: 1.08 (95% CI 0.51–2.31) 1196 patients from 2 studies |
227 per 1000 |
245 per 1000 |
low due to serious risk of bias and serious imprecision |
| difference: 18 more per 1000 (95% CI 111 less to 297 more) | ||||
| Intubation or death at 28 days | RR 0.86 (95% CI 0.75–0.98) 1121 patients from 1 study |
461 per 1000 |
396 per 1000 |
moderate due to serious risk of bias |
| difference: 65 less per 1000 (95% CI 115 less to 9 less) | ||||
| Intubation within 28 days | RR 0.83 (95% CI 0.71–0.96) 1196 patients from 2 studies |
396 per 1000 |
329 per 1000 |
moderate due to serious risk of bias |
| difference: 67 less per 1000 (95% CI 115 less to 16 less) | ||||
| Hospital length of stay (censored at 28 days) |
difference of means −0.2 days 1196 patients from 2 studies |
16.6 days | 16.4 days | moderate due to serious risk of bias |
| difference: 0.2 days less (95% CI 1.35 less to 0.96 more) | ||||
| Days free of HFNC within 30 days | difference of means 2 days 50 patients from 1 study |
24 days | 26 days | low due to serious risk of bias and serious imprecision |
| difference: 2.0 days more (95% CI 0.13 more to 3.87 more) | ||||
| Weaning of HFNC (time to event within 28 days) | difference of means 0.9 days 1121 patients from 1 study |
6.0 days | 6.9 days | moderate due to serious risk of bias |
| difference: 0.9 days more (95% CI 0.35 more to 1.45 more) | ||||
| Skin lesions within 28 days | RR 0.5 (95% CI 0.16–1.56) 1196 patients from 2 studies |
32 per 1000 |
16 per 1000 |
very low due to serious risk of bias and very serious imprecision |
| difference: 16 less per 1000 (95% CI 27 less to 18 more) | ||||