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. 2022 Jan 2;10(1):69. doi: 10.3390/vaccines10010069

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RBD-SD1-Fc antigen construction. (A) Schematic structure of SARS-CoV-2 envelope; (B) Graphical representation of the human S protein with signal peptide (SP), N-terminal domain (NTD), receptor-binding domain (RBD), SD1 and SD2 subdomains, fusion peptide (FP), heptad repeat 1/2 (HR1/2), and the transmembrane domain (TM). The cleavage sites are indicated by arrows. Adapted from [15]. Sequence cloned for antigen construction is indicated by green line; (C) Construction of Betuvax-CoV-2 antigen; (D) SDS-PAGE analysis of purified RBD-SD1-Fc protein (M—marker), 10 µg load.