Table 2.
Epidemiology of EVs infection in newborn and infants.
| Author-Year | Verboon-Maciolek-2008 | Rodà-2015 | Cabrerizo-2015 | Lv-2016 | Cabrerizo-2017 | Kadambari-2019 |
|---|---|---|---|---|---|---|
| Reference | [11] | [12] | [13] | [14] | [15] | [16] |
| Country | Netherlands | Spain | Spain | China | Spain | UK-Ireland |
| Single center/multicenter | Single centre | Single centre | Multicentre | Single centre | Multicentre | Multicentre |
| Period in study | Jan 1994–Dec 2016 | Mar 2010–Dec 2010 | Jan 2013–Dec 2013 | Mar 2011–Sep 2012 | Jan 2010–Dec 2013 | Jul 2014–Jul 2015 |
| Age at diagnosis (d) | 0–30 | 0–90 | 0–30 | 0–30 | 0–30 | 0–90 |
| Inclusion criteria | EVs confirmed cases | Fever > 38 °C | Fever > 38 °C, ME, CS | Fever > 38 °C | Fever > 38 °C, ME CS, HFMD, AE | ME |
| positive/tested (%) | 21/21 (100) | 195/699 (28) | 32/84 (38) | 131/334 (39) | 249/1430 (17) | 668/668 (100) |
| M/F | 14/7 | 114/81 | 17/15 | 85/46 | ||
| Predominant serotypes (%) | CV-B5 (33) | E-5 (21.1) | E-18 (24) | CV-B1 (47) | E-5 | E-9 (20) |
| E-11 (9.5) | E-11 (11.8) | E-3 (14) | E-30 (35) | E-11 | E-18 (12) | |
| E-6 (9.5) | E-21 (7.2) | E-5 (14) | CV-B3 (10) | CV-B4 | CV-B5 (8) | |
| CV-A9 (9.5) | E-25 (7.2) | CV-B3 (10) | E-16 (4) | CV-B4 (7) | ||
| Other (28.6) | CV-B4 (6.4) | Other (38) | E-25 (6) | |||
| Seasonal Period (%) | Jun–Oct (62) | Mar–Aug (73) | Apr–Jul (66) | Mar–Aug (100) | Apr–Jun (50) | Summer (ns) |
ME, meningoencephalitis; CS, clinical sepsis; HFMD, hand foot and mouth disease; AE, atypical exanthem; CV, coxsackievirus; E, Echovirus; ns, not specified; M/F, male/female.