TABLE 3.
Variability in retinal cell transduction by different adeno-associated virus (AAV) capsid serotypes. Relative transduction efficiencies are shown for AAV capsid serotypes each carrying an AAV2 vector with a green fluorescent protein (GFP) gene under the control of a human cytomegalovirus (hCMV) promoter. These were used to transduce cadaveric human retinal explants. Data derived from Wiley et al. (2018).
| AAV capsid serotype | Relative transduction efficiency in human retinal explants | ||
|---|---|---|---|
| ONL | INL | GCL and NFL | |
| AAV1 | High | Low | High |
| AAV2 | Intermediate | Intermediate | High |
| AAV4 | High | High | High |
| AAV5 | Intermediate/high | Low | Low |
| AAV6 | Intermediate/high | High | High |
| AAV8 | Low | Intermediate | High |
| AAV9 | Intermediate | Intermediate | High |