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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Hepatology. 2021 Jul 29;74(4):1845–1863. doi: 10.1002/hep.31871

Figure 8. Working model of biliary SCT/SCTR/miR-125b axis regulation of biliary damage, steatosis, and hepatic fibrosis in NAFLD/NASH.

Figure 8.

Biliary SCT and SCTR expression is increased in NAFLD. SCT/SCTR downregulation biliary miR-125b promotes steatosis by targeting lipogenesis gene ELOVL1 in NAFLD. Increased cholangiocyte-derived TGF-β1 induces HSC activation by paracrine in NAFLD.