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Measures to prevent LSEC aging. Nanoparticle targeted drug delivery can be used for the regulation of fenestrations in LSECs. Resveratrol and metformin act on sirtuin and AMPK nutrient‐sensitive pathways respectively to regulate the aging of LSECs. Calorie restriction can reduce the occurrence of pseudocapillarization and thus affect the aging of LSECs. Statins reduce the occurrence of LSEC aging by increasing the autophagy of LSECs
