Table 2. Concentrations (pg/ml) of immune mediator expression in aqueous humor (AH) from 75 samples of patients with idiopathic uveitis and 36 samples of noninflammatory controls patients (age-related cataract). n = patients number.
Groups | |||
---|---|---|---|
Variable | Idiopathic uveitis, n = 75 | Noninflammatory controls (age-related cataract without uveitis), n = 42 | P* |
IL-1β | 0 [0–0.46] | 0 [0–0.43] | 0.1033 |
IL-1Rα | 50.92 [0–126.9] | 0.83 [0–61.69] | 0.0342 |
IL-2 | 0 [0–0] | 0 [0–0] | 0.8926 |
IL-4 | 0 [0–0] | 0 [0–0,4] | 0.0439 |
IL-5 | 0 [0–5.52] | 0 [0–0] | <0.0001 |
IL-6 | 81.73 [8.82–511.2] | 6.64 [2.3–40.96] | 0.0079 |
IL-7 | 0 [0–18.72] | 7.63 [1.89–33.11] | 0.1194 |
IL-8 | 22.23 [2.12–87.86] | 2.76 [1.62–6.36] | 0.0013 |
IL-9 | 2.85 [0–8.8] | 0 [0–0.34] | 0.0004 |
IL-10 | 0 [0–10.18] | 0.35 [0–2.16] | 0.1115 |
IL-12 | 11.13 [5.67–20.49] | 3.3 [1.07–6.57] | <0.0001 |
IL-13 | 0.46 [0–3.9] | 0.1 [0–1.08] | 0.2153 |
IL-15 | 0 [0–0] | 0 [0–8.56] | 0.0042 |
IL-17 | 0 [0–9.96] | 0 [0–115.0] | 0.0204 |
IL-21 | 0 [0–26.09] | 0 [0–0] | 0.0504 |
IL-23 | 0 [0–4.92] | 0 [0–0] | 0.0338 |
Eotaxin | 6.29 [0–30.61] | 0 [0–0] | <0.0001 |
FGF-basic | 0 [0–0] | 0 [0–0] | 0.1238 |
G-CSF | 9.98 [1.47–113.3] | 0.64 [0–1.89] | <0.0001 |
GM-CSF | 0 [0–100.4] | 0 [0–2.39] | 0.1270 |
IFN-γ | 0 [0–0] | 0 [0–0] | 0.1119 |
IP-10 | 4442 [462.8–17790] | 284.7 [134.8–484.6] | <0.0001 |
MCP-1 | 125.2 [46.24–315.8] | 59 [4.11–95.26] | <0.0001 |
MIP-1α | 1.21 [0–2.66] | 0 [0–0] | 0.00001 |
PDGF-bb | 0 [0–0] | 1.69 [0–13.46] | 0.0728 |
MIP-1β | 27.2 [11.16–47.61] | 0 [0–7.88] | <0.0001 |
RANTES | 0 [0–0] | 0 [0–0] | 0.1656 |
TNF-α | 0 [0–6.3] | 0 [0–0] | 0.0006 |
VEGF | 79.19 [26.84–160.6] | 0 [0–24.37] | <0.0001 |
*Significant P values are noted in right column of the Table. Statistical analysis was done with non parametric Kruskal-Wallis and Fisher’s exact tests for the comparison of dosage of different cytokines between idiopathic uveitis and controls in aqueous humor (medianes of concentrations). A P value < 0.05 was considered significant.