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. 2022 Jan 21;17(1):e0254972. doi: 10.1371/journal.pone.0254972

Table 2. Concentrations (pg/ml) of immune mediator expression in aqueous humor (AH) from 75 samples of patients with idiopathic uveitis and 36 samples of noninflammatory controls patients (age-related cataract). n = patients number.

Groups
Variable Idiopathic uveitis, n = 75 Noninflammatory controls (age-related cataract without uveitis), n = 42 P*
IL-1β 0 [0–0.46] 0 [0–0.43] 0.1033
IL-1Rα 50.92 [0–126.9] 0.83 [0–61.69] 0.0342
IL-2 0 [0–0] 0 [0–0] 0.8926
IL-4 0 [0–0] 0 [0–0,4] 0.0439
IL-5 0 [0–5.52] 0 [0–0] <0.0001
IL-6 81.73 [8.82–511.2] 6.64 [2.3–40.96] 0.0079
IL-7 0 [0–18.72] 7.63 [1.89–33.11] 0.1194
IL-8 22.23 [2.12–87.86] 2.76 [1.62–6.36] 0.0013
IL-9 2.85 [0–8.8] 0 [0–0.34] 0.0004
IL-10 0 [0–10.18] 0.35 [0–2.16] 0.1115
IL-12 11.13 [5.67–20.49] 3.3 [1.07–6.57] <0.0001
IL-13 0.46 [0–3.9] 0.1 [0–1.08] 0.2153
IL-15 0 [0–0] 0 [0–8.56] 0.0042
IL-17 0 [0–9.96] 0 [0–115.0] 0.0204
IL-21 0 [0–26.09] 0 [0–0] 0.0504
IL-23 0 [0–4.92] 0 [0–0] 0.0338
Eotaxin 6.29 [0–30.61] 0 [0–0] <0.0001
FGF-basic 0 [0–0] 0 [0–0] 0.1238
G-CSF 9.98 [1.47–113.3] 0.64 [0–1.89] <0.0001
GM-CSF 0 [0–100.4] 0 [0–2.39] 0.1270
IFN-γ 0 [0–0] 0 [0–0] 0.1119
IP-10 4442 [462.8–17790] 284.7 [134.8–484.6] <0.0001
MCP-1 125.2 [46.24–315.8] 59 [4.11–95.26] <0.0001
MIP-1α 1.21 [0–2.66] 0 [0–0] 0.00001
PDGF-bb 0 [0–0] 1.69 [0–13.46] 0.0728
MIP-1β 27.2 [11.16–47.61] 0 [0–7.88] <0.0001
RANTES 0 [0–0] 0 [0–0] 0.1656
TNF-α 0 [0–6.3] 0 [0–0] 0.0006
VEGF 79.19 [26.84–160.6] 0 [0–24.37] <0.0001

*Significant P values are noted in right column of the Table. Statistical analysis was done with non parametric Kruskal-Wallis and Fisher’s exact tests for the comparison of dosage of different cytokines between idiopathic uveitis and controls in aqueous humor (medianes of concentrations). A P value < 0.05 was considered significant.