Table 2. Association between fatty liver index and incidence of adult-onset asthma.

			Univariate			Model 1*			Model 2†
	Total (N)	Event (n, %)	HR	95% CI	P value	HR	(95% CI)	P value	HR	95% CI	P value
FLI group
0≤ FLI <30	136,094	13,744(10.1)	Reference			Reference			Reference
30≤ FLI < 60	18,373	1,986 (10.8)	1.04	0.99–1.09	0.06	1.13	1.07–1.18	<0.001	1.14	1.08–1.20	<0.001
FLI ≥60	6136	647 (10.5)	1.04	0.96–1.12	0.28	1.23	1.13–1.33	<0.001	1.25	1.15–1.36	<0.001
FLI criteria ‡
low likelihood	103630	9846(9.5)	Reference			Reference			Reference
intermediate likelihood	25797	2943(11.4)	1.11	1.06–1.14	< 0.001	1.09	1.05–1.13	0.001	1.10	1.06–1.14	< 0.001
High likelihood	31176	3588(11.5)	1.12	1.08–1.15	< 0.001	1.17	1.13–1.19	< 0.001	1.18	1.14–1.22	< 0.001
HSI
HSI < 36	139608	14044(10.1)	Reference			Reference			Reference
HSI ≥36	20995	2333(11.1)	1.10	1.06–1.15	< 0.001	1.09	1.04–1.14	<0.001	1.12	1.07–1.17	<0.001

*Cox proportional hazard models including age, and sex as covariates.

^†Cox proportional hazard models including Model 1 plus activity, drinking, systolic blood pressure, diastolic blood pressure, fast blood glucose and low-density lipoprotein cholesterol as covariates.

^‡Low likelihood: 0≤ FLI <25 for male, 0≤ FLI <10 for female; intermediate likelihood: 25≤ FLI< 35 for male, 10≤ FLI <20 for female; high likelihood: FLI ≥35 for male, FLI ≥20 for female.

Abbreviations: CI = confidence interval; FLI = fatty liver index; HR = hazard ratio; HSI = Hepatic steatosis.