Table 5. Clinical observations of an acute oral toxicity study for βCD/PVP-co-poly (AMPS) nanogels.

Observations	Group I (control)	Group II (treated with nanogels)	p-value
Sign of illness	Nil	Nil
Food intake (g)
Preliminary to therapy	67.37 ± 1.62	68.42 ± 2.19	0.631
Day 1	69.12 ± 1.52	71.21 ± 3.17
Day 7	73.14 ± 1.03	73.29 ± 2.51
Day 14	75.42 ± 2.08	75.61 ± 4.03
Water intake (ml)
Preliminary to therapy	189.14 ± 4.19	187.14 ± 2.11	0.521
Day 1	191.63 ± 2.33	190.62 ± 1.62
Day 7	201.01 ± 1.42	196.19 ± 1.02
Day 14	203.21 ± 3.19	199.64 ± 3.41
Body weight (kg)
Preliminary to therapy	2.03 ± 0.01	2.08 ± 0.05	0.417
Day 1	2.06 ± 0.03	2.11 ± 0.01
Day 7	2.07 ± 0.07	2.12 ± 0.04
Day 14	2.09 ± 0.06	2.14 ± 0.03
Other Toxicological Observations
Ocular toxicity	Nil	Nil
Dermal toxicity	Nil	Nil
Simple irritation	Nil	Nil
Mortality rate	Nil	Nil

Note. All values are expressed as mean ± SD (n = 12).

The value of “p” less than 0.05 was considered significant.