Table 6. Hematology, biochemical parameters and consequences of orally administered βCD /PVP-co-poly (AMPS) nanogels on organ weight (g) of rabbits.
| Biochemical blood analysis | |||
| Parameter/test | Group I (control) | Group II (treated with nanogel) | p-value |
| White blood cells ×109/L | 6.93 ± 0.81 | 7.21 ± 0.24 | 0.230 |
| Platelets × 109/L | 4.23 ± 1.26 | 4.61± 1.19 | 0.851 |
| Hemoglobin (g/dl) | 12.96 ± 1.39 | 13.06 ± 1.36 | 0.501 |
| Red blood cells 106/mm3 | 5.97 ± 0.76 | 6.15 ± 0.21 | 0.744 |
| Neutrophils (%) | 55.04 ± 2.62 | 54.95 ± 3.01 | 0.327 |
| Lymphocytes (%) | 65.10 ± 0.08 | 64.15 ± 1.32 | 0.901 |
| Monocytes (%) | 3.51 ± 2.04 | 3.52 ± 1.09 | 0.567 |
| Mean corpuscular Volume MCV(%) | 63.72 ± 1.01 | 66.08 ± 1.42 | 0.366 |
| Mean corpuscular hemoglobin MCH (pg/cell) | 24.17 ± 1.81 | 27.47 ± 1.41 | 0.793 |
| Mean corpuscular hemoglobin concentration MCHC (%) | 31.07 ± 1.26 | 32.53 ± 1.21 | 0.250 |
| Biochemical parameters | |||
| ALT/SGPT (IU/L) | 29.10 ± 1.41 | 30.21 ± 1.32 | 0.606 |
| AST/SGOT (IU/L) | 142.0 ± 0.17 | 141.17 ± 0.51 | 0.670 |
| Cholesterol (mg/dl) | 62.42 ± 3.14 | 65.16 ± 2.15 | 0.935 |
| Creatinine (mg/dl) | 0.94 ± 0.02 | 0.96 ± 0.08 | 0.914 |
| Serum urea (mg/dl) | 14.23 ± 0.04 | 16.70 ± 0.03 | 0.885 |
| Triglycerides (mg/dl) | 53.37 ± 2.47 | 54.27 ± 2.18 | 0.873 |
| Serum uric acid (mg/dl) | 3.24 ± 0.13 | 3.39 ± 0.19 | 0.741 |
| Organ weight(g) of Rabbits | |||
| Heart | 4.09 ± 0.49 | 3.39 ± 0.58 | 0.468 |
| Liver | 10.08± 1.09 | 9.23 ± 1.22 | 0.704 |
| Stomach | 13.29 ± 0.27 | 11.61 ± 0.36 | 0.931 |
| Kidney | 10.83± 1.29 | 12.56 ± 1.01 | 0.879 |
| Lung | 9.53 ± 0.24 | 8.91 ± 0.42 | 0.369 |
| Spleen | 1.32 ± 0.11 | 1.39 ± 0.18 | 0.960 |
Note. All values are expressed as mean ± SD (n = 12).
The value of “p” less than 0.05 was considered significant.