Table 8. Mean values of pharmacokinetic parameters of rosuvastatin following administration of oral tablet and oral nanogel in rabbits (n = 12).
| Pharmacokinetic parameter | Commercial Tablet | Hydrogel Nanoparticles | p-value |
|---|---|---|---|
| Cmax (ng ml-1) | 41.11 ± 2.07 | 83.34.34 ± 8.23 | 0.011 |
| Tmax (h) | 4 ± 0.72 | 3 ± 0.17 | 0.135 |
| t1/2 (h) | 7.21 ± 3.41 | 8.60 ± 9.87 | 0.464 |
| AUC 0–t (ng ml-1.h) | 514.43± 39.58 | 923.44± 69.37 | 0.0001 |
| AUC 0–∞ (ng ml-1.h) | 562.80± 27.67 | 1061.56 ± 109.43 | 0.0008 |
| AUMC (ng/ml*h^2) | 6750.24 | 13967.97 | 0.004 |
| MRT (h) | 11.99 ± 1.94 | 13.16 ± 13.49 | 0.017 |
Note. All values are expressed as mean ± SD (n = 12).
The value of “p” less than 0.05 was considered significant.