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Different generations of CAR T cells and their signaling pathways. TM: Transmembrane; scFv: Single-chain variable Fragment; VL: Variable Light chain; VH: Variable Heavy chain; IL2RB: interleukin 2 Receptor B; mTORC: mammalian target of rapamycin complex; FAO: Fatty Acid Oxidation; JAK-STAT: Janus Kinase-Signal Transducers and Activators of Transcription; PI3K: Phosphoinositide 3-kinase; Akt: Protein kinase; CART: Chimeric Antigen Receptor T cell. Figure generated.
