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. 2021 Dec 30;14(1):183. doi: 10.3390/cancers14010183

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunometabolism shapes the epigenome of T cells. Here several of these epigenetic modifying pathways and metabolites influencing histone modification are outlined. OAA: Oxaloacetate; a-KG: a-Ketoglutarate; S2HG: S-2-hydroxyglutarate; DNMTs: DNA methyltransferase; EZH2: Enhancer of zeste homolog 2; SAM: S-adenosyl methionine; SAH: S-adenosyl homocysteine; NAD+: Nicotinamide adenine dinucleotide; NADH: Nicotinamide adenine dinucleotide hydrogen; HDACs: Histone deacetylases; HATs: Histone acetyltransferase. Figure generated by Biorender.com (accessed on 15 November 2021).