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. 2021 Dec 30;14(1):183. doi: 10.3390/cancers14010183

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Overview of CAR NK cell generations. Depicted designs are representative of CAR NK cells resistant to challenges within the tumor microenvironment that limit NK cell metabolism and CAR NK cells with reported improvement of metabolic features. MDSCs, myeloid-derived suppressor cells; TGFβ, transforming growth factor β; tCD19, truncated CD19; GVHD, graft-versus-host disease; OXPHOS, oxidative phosphorylation; aa, amino acid. Figure generated by Biorender.com (accessed on 15 November 2021).