Table 2. IPA for disease pathways and functions enriched in data set of differentially expressed genes between Holstein and Sahiwal T. annulata infected cell lines.

Category	Diseases or Functions Annotation	p-value	Predicted Activation State	Activation z-score	# Molecules
Antimicrobial Response, Inflammatory Response	Antiviral response	<0.001	Decreased	-3.341	48
Inflammatory Response	Immune response of cells	<0.001	Decreased	-2.725	84
Antimicrobial Response, Inflammatory Response	Antimicrobial response	<0.001	Decreased	-3.107	56
Neurological Disease	Progressive neurological disorder	<0.001	Decreased	-2.157	133
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	Urinary tract cancer	<0.001	Decreased	-2.236	240
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	Renal cancer	<0.001	Decreased	-2.236	150
Cell Death and Survival	Cell death of lymphoma cell lines	<0.001	Decreased	-3.104	36
Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism	Synthesis of cholesterol	<0.001	Decreased	-2	18
Cell Death and Survival	Apoptosis of lymphoma cell lines	<0.001	Decreased	-2.81	29
Cell Death and Survival	Cell death of macrophage cancer cell lines	<0.001	Decreased	-2.735	11
Cell Death and Survival	Cell death of connective tissue cells	<0.001	Decreased	-2.034	75
Cell-To-Cell Signalling and Interaction, Inflammatory Response	Response of phagocytes	0.002	Decreased	-2.498	32
Cell-To-Cell Signalling and Interaction, Embryonic Development	Response of embryonic cell lines	0.002	Decreased	-3.111	12
Cell-To-Cell Signalling and Interaction	Response of myeloid cells	0.003	Decreased	-2.466	31
Cell-To-Cell Signalling and Interaction, Inflammatory Response	Immune response of phagocytes	0.003	Decreased	-2.787	29
Embryonic Development, Organismal Development	Development of body trunk	<0.001	Increased	3.647	153
Infectious Diseases	Viral Infection	<0.001	Increased	3.15	220
Infectious Diseases	Infection by RNA virus	<0.001	Increased	3.075	114
Cancer, Organismal Injury and Abnormalities	Development of malignant tumour	<0.001	Increased	2.984	786
Infectious Diseases	Infection of Mammalia	0.001	Increased	2.978	42
Cellular Movement	Cell movement of melanoma cell lines	0.002	Increased	2.715	21
Infectious Diseases	Replication of Herpesviridae	<0.001	Increased	2.449	15
Cancer, Organismal Injury and Abnormalities	Incidence of tumour	<0.001	Increased	2.428	815
Infectious Diseases	Infection of cells	<0.001	Increased	2.331	97
Cancer, Organismal Injury and Abnormalities	Malignant solid tumour	<0.001	Increased	2.277	1292
Infectious Diseases	Replication of Murine herpesvirus 4	0.003	Increased	2.236	5
Cardiovascular System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development	Cardiogenesis	<0.001	Increased	2.198	79
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	Tumorigenesis of reproductive tract	<0.001	Increased	2.19	459
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	Female genital neoplasm	<0.001	Increased	2.19	459
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease	Ovarian tumour	<0.001	Increased	2.19	205
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	Endocrine gland tumour	<0.001	Increased	2.183	1024
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	Digestive organ tumour	<0.001	Increased	2.161	1130
Cancer, Organismal Injury and Abnormalities	Frequency of tumour	<0.001	Increased	2.152	801
Cancer, Haematological Disease, Organismal Injury and Abnormalities	Hematologic cancer	0.002	Increased	2.088	329
Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities	Liver tumour	<0.001	Increased	2.017	556