Table 3. Top activated or repressed upstream regulators predicted by IPA from gene targets within the H/S-DE data set.
| Upstream Regulator | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap | Genes in dataset (Number of regulators from data in network) |
|---|---|---|---|---|---|
| IFNA2 | cytokine | Inhibited | -5.284 | <0.001 | 108 (11) |
| IRF7 | transcription regulator | Inhibited | -5.147 | <0.001 | 137 (13) |
| Interferon alpha | group | Inhibited | -5.024 | <0.001 | 180 (13) |
| IRF3 | transcription regulator | Inhibited | -4.863 | <0.001 | 120 (12) |
| PRL | cytokine | Inhibited | -4.788 | <0.001 | 241 (10) |
| poly rI:rC-RNA | biologic drug | Inhibited | -4.586 | <0.001 | 292 (13) |
| IFNL1 | cytokine | Inhibited | -4.577 | <0.001 | 374 (15) |
| IFN Beta | group | Inhibited | -4.506 | <0.001 | 233 (11) |
| STAT1 | transcription regulator | Inhibited | -4.412 | <0.001 | 318 (12) |
| Ifnar | group | Inhibited | -4.245 | <0.001 | 181 (14) |
| IFNG | cytokine | Inhibited | -4.078 | <0.001 | 367 (14) |
| IRF1 | transcription regulator | Inhibited | -3.994 | <0.001 | 317 (13) |
| CpG ODN 2006 | chemical reagent | Inhibited | -3.846 | <0.001 | 244 (11) |
| IFNB1 | cytokine | Inhibited | -3.806 | <0.001 | 286 (13) |
| IRF5 | transcription regulator | Inhibited | -3.763 | <0.001 | 357 (17) |
| IFNA1/IFNA13 | cytokine | Inhibited | -3.538 | <0.001 | 103 (10) |
| TGM2 | enzyme | Inhibited | -3.516 | <0.001 | |
| SREBF2 | transcription regulator | Inhibited | -3.482 | <0.001 | 250 (5) |
| TRIM24 | transcription regulator | Activated | 4.884 | <0.001 | 68 (6) |
| MAPK1 | kinase | Activated | 4.26 | <0.001 | 106 (8) |
| PNPT1 | enzyme | Activated | 4.123 | <0.001 | 260 (7) |
| NKX2-3 | transcription regulator | Activated | 3.788 | <0.001 | |
| INSIG1 | other | Activated | 3.628 | <0.001 | 190 (5) |
| ACKR2 | G-protein coupled receptor | Activated | 3.606 | <0.001 | 233 (5) |
| PTGER4 | G-protein coupled receptor | Activated | 3.286 | <0.001 | 363 (10) |
| MYC | transcription regulator | Activated | 3.202 | <0.001 | 231 (2) |
| SIRT1 | transcription regulator | Activated | 3.184 | 0.0582 | |
| SOCS1 | other | Activated | 3.18 | 0.015 | |
| MFSD2A | transporter | Activated | 3.148 | <0.001 | |
| IL1RN | cytokine | Activated | 3.048 | <0.001 | 362 (11) |
| LEPR | transmembrane receptor | Activated | 3 | 0.219 | |
| Mek | group | Activated | 2.992 | 0.475 | |
| MMP3 | peptidase | Activated | 2.828 | 0.351 | |
| IRF8 | transcription regulator | Activated | 2.819 | 0.016 | |
| JQ1 | chemical reagent | Activated | 2.779 | 0.055 | |
| USP18 | peptidase | Activated | 2.772 | <0.001 | 72 (9) |
| POR | enzyme | Activated | 2.729 | <0.001 | |
| IKZF3 | transcription regulator | Activated | 2.72 | 0.005 | |
| HMGA1 | transcription regulator | Activated | 2.718 | 0.337 |