Table 5. Outcome according to the use of megadoses.
| WITH CS No. (Total n = 5,262) | Low-dose CS (n = 2,578) No (%) | CS Megadoses (n = 2,216) No (%) | Odds ratio (IC 95%) | P value | |
|---|---|---|---|---|---|
| Hospital stay in days, median (IQR) | 4,794 | 12 (7–18) | 12 (8–19) | 0.99 (0.99–1.01) | 0.88 |
| High-flow nasal cannula | 4,767 | 325 (12.7) | 340 (15.4) | 1.25 (1.06–1.47) | 0.008 |
| Non-invasive mechanical ventilation | 4,778 | 214 (8.3) | 243 (11.0) | 1.36 (1.12–1.65) | 0.002 |
| Invasive mechanical ventilation | 4,782 | 307 (12.0) | 250 (11.3) | 0.94 (0.79–1.12) | 0.49 |
| Prone position | 4,774 | 413 (16.1) | 586 (26.6) | 1.89 (1.64–2.17) | <0.001 |
| ICU admission | 4,793 | 370 (14.4) | 332 (15.0) | 1.05 (0.90–1.23) | 0.54 |
| Resolution of first episode | |||||
| Discharge home | 4,794 | 1,656 (64.2) | 1,509 (68.1) | 1 (ref.) | - |
| Convalescence centre | 139 (5.4) | 108 (4.9) | 0.85 (0.66–1.11) | 0.23 | |
| Death during hospital admission | 783 (30.4) | 599 (27.0) | 0.84 (0.74–0.95) | 0.007 | |
| Readmission to hospital | |||||
| Readmission | 4,630 | 130 (5.2) | 75 (3.5) | 0.66 (0.49–0.88) | 0.005 |
| Days of discharge to readmission, median (IQR) | 205 | 8.5 (2–16) | 12 (5–15) | 1.02 (0.99–1.05) | 0.12 |
| Mortality 1 | 4,750 | 803 (31.4) | 608 (27.7) | 0.84 (0.74–0.95) | 0.005 |
ICU = Intensive care unit, CS = Corticosteroids.
1: Death at any time. Either on first admission, on discharge or on re-admission.