Table 1.

Drugs available targeting AKT.

Drugs	Manipulation of AKT Activity	Outcome	Refs
DIM	Decreased	activates the mitochondrial pathway in malignant melanoma cells, suppresses the proliferation of cells and induces cell apoptosis.	[121]
AS-IV	Increased	relieves ischemic-induced myocardial apoptosis, alleviates myocardium impairment, promotes angiogenesis.	[140]
NBP	Increased	attenuates social deficits and anxiety-like behavior.	[164]
THSG	Increased	improves the behavioral performances of depressive-like mice.	[165]
NR	Increased	ameliorates alcohol-induced depressive behaviours.	[167]
Vanillic acid	Increased	demonstrates antidepressant effects by reducing behavioral despair in the FST.	[168]
Li+, VPA, and CBZ	Increased	increases glycogen content in astrocytes, which may be responsible for therapeutic effects of these drugs.	[181]

Abbreviations: DIM, 3,3′-diindolylmethane; AS-IV, Astragaloside IV; NBP, Dl-3-n-butylphthalide; THSG, 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside; NR, Nicotinamide riboside; Li⁺, lithium salts; VPA, valproic acid; CBZ, carbamazepine; FST, forced swim test; Refs, References.