Figure 5. Correlations of month 3 transcriptional and adaptive responses in RTS,S/AS01 vaccine recipients.

Heatmap showing correlations between month 3 levels of RTS,S/AS01 signature blood transcriptional modules (BTMs) in vehicle-treated peripheral blood mononuclear cells (PBMC) and month 3 antibody responses. Cell color intensity represents the strength of the correlation; BTM/response pairs with significant correlations (false discovery rate [FDR] ≤0.2) are outlined in black. Cell color represents correlation direction: red, positive correlation; blue, negative correlation. High-level BTM annotation groups are shown in the left-most color bar. Number of participants: 30–42.

Figure 5—figure supplement 1. Correlations of transcriptional and adaptive responses in comparator vaccine recipients.

Heatmap showing significant correlations between month 3 levels of RTS,S/AS01 signature blood transcriptional modules (BTMs) in vehicle-treated peripheral blood mononuclear cells (PBMC) and month 3 antibody responses in comparator recipients. Cell color intensity represents the strength of the correlation; BTM/response pairs with significant correlations (false discovery rate [FDR] ≤0.2) are outlined in black. Cell color represents correlation direction: red, positive correlation; blue, negative correlation. High-level BTM annotation groups are shown in the left-most color bar. No correlations with month 3 cellular responses were seen.