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. 2021 Oct 5;13(11):822–833. doi: 10.1093/jmcb/mjab060

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© The Author(s) (2021). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Assessments of the tipping point and core DNB genes of skin response to UVB irradiation. (A) DNB scores calculated by just core DNB genes or by all candidate DNB genes. (B) Comparison of the onset time and efficacy between USBT2627 treatments before and after the tipping point. Onset time: the time when skin sample showed significant increase of L*. Efficacy: normalized increasement of L* in USBT2627 group compared to UVB group at onset time. (C) Melanin staining between USBT2627 treatments before and after the tipping point.