Figure 3.
Genetically obese mice fed a ketogenic exhibit decreased methacholine hyperresponsiveness. Wild-type (WT) or Leprdb/db (DbDb) mice were maintained on a normal diet (Chow) or switched to a ketogenic diet (KD) for 3 wk. Body weight was measured pre- and postswitching diets (A). Serum β-hydroxybutyrate (BHB) (B), total bronchoalveolar lavage (BAL) cells (C), airway resistance (RN) (D), tissue damping (G) (E), and tissue elastance (H) (F) were measured at the end of the study; n = 8–9 mice/group. *P ≤ 0.05, **P ≤ 0.01, ****P ≤ 0.0001, compared with indicated group.