Table 2.
Neuropsychological test scores by cognitive class
| Cognitive Domain Test | PD-NC | PD-MCI | PDD | F/t/χ2 Value | P Value |
|---|---|---|---|---|---|
| Global cognition | |||||
| DRS-2 total | 137.32 (5.03), 129–143 | 133.76 (4.97), 124–144 | 115.53 (15.67), 82–143 | 23.346 | 0.000003 |
| MoCA | 27.63 (1.21), 25–30 | 23.12 (4.02), 16–28 | 18.85 (6.22), 9–26 | 14.370 | 0.00004 |
| Global cognition composite score | 0.87 (.23), 0.03 to 1.11 | 0.09 (0.43), −0.04 to 1.03 | −1.07 (1.25), −4.00 to 0.47 | 17.684 | 0.000001 |
| Attention | |||||
| Trails A | 37.97 (16.02), 23.0–76.2 | 49.05 (15.16), 28.68–79.0 | 107.01 (109.72), 29–352 | 6.023 | 0.006 |
| BTA | 14.13 (2.97), 7–19 | 11.59 (4.78), 5–19 | 10.25 (7.13), 2–20 | 2.359 | 0.081 |
| Attention composite score | 0.33 (0.63), −0.72 to 1.09 | 0.28 (0.64), −1.31 to 1.04 | 0.25 (0.81), −1.48 to 1.02 | 1.465 | 0.092 |
| Language | |||||
| BNT | 57.12 (3.42), 47–60 | 55.47(3.13), 49–60 | 55.78 (3.68), 47–60 | 0.596 | 0.685 |
| Verbal fluency | 50.65 (11.61), 34–65 | 34.65 (13.95), 17–62 | 25.76 (11.35), 18–49 | 6.952 | 0.003 |
| Language composite score | 0.59 (0.42), −0.19 to 1.45 | −0.12 (1.07), −2.05 to 1.32 | −0.43 (0.86), −1.89 to 1.10 | 2.309 | 0.114 |
| Learning and memory | |||||
| CVLT (1–5) | 41.01 (6.21), 31–60 | 31.78 (7.25), 21–53 | 28.88 (16.25), 15–69 | 6.987 | 0.005 |
| CVLT long delay free recall | 9.45 (3.01), 4–14 | 6.78 (3.59), 0–13 | 3.25 (4.37), 0–12 | 6.844 | 0.003 |
| Learning and memory composite score | 0.54 (0.84), −0.92 to 2.12 | −0.18 (0.73), −1.70 to 1.07 | −0.15 (1.38), −2.11 to 1.17 | 6.821 | 0.004 |
| Executive function | |||||
| Trails B | 91.25 (26.18), 61–163.04 | 137.52 (57.25), 69–264.37 | 251.73 (153.87), 48–512 | 8.894 | 0.001 |
| SDMT oral | 50.54 (8.25), 24–67 | 35.44 (11.22), 15–58 | 28.97 (13.25), 16–53 | 8.703 | 0.001 |
| Executive function composite score | 0.59 (0.65), −0.97 to 1.11 | −0.10 (0.76), −1.34 to 1.45 | −0.29 (0.84), −1.86–1.09 | 6.875 | 0.002 |
| Visuospatial | |||||
| JLO | 29.27 (4.28), 21–30 | 25.52 (4.25), 17–30 | 24.60 (5.46), 12–29 | 1.479 | 0.081 |
Data presented as means (SD), range. BNT, Boston Naming Test; BTA, Brief Test of Attention; CVLT, California Verbal Learning Test; DRS-2, Dementia Rating Scale; JLO, Judgment of Line Orientation; MoCA, Montreal Cognitive Assessment; PDD, Parkinson’s disease dementia; PD-MCI, Parkinson’s disease mild cognitive impairment; PD-NC, Parkinson’s disease normal cognition; SDMT, Symbol Digit Modalities Test.