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. 2021 Dec 13;322(2):F164–F174. doi: 10.1152/ajprenal.00353.2021

Figure 3.

Figure 3.

Interleukin-1 receptor type 1 (IL-1R1) deletion in podocytes augments albuminuria and podocyte injury induced by adriamycin (ADR) in mice. A: urinary albumin concentration in wild-type (WT) and podocyte-specific knockout (PKO) mice at days 1 and 3 after ADR injection (n = 10). B: representative SDS-PAGE showing the urine proteins at day 3 in groups. C: Western blots for podocin and nephrin in glomeruli isolated from WT and PKO mice 3 days after ADR injection. D: semiquantitative determination of podocin and nephrin protein from the blots shown in C (n = 4–6). E: representative immunostaining for nephrin protein in different groups. P values in A and D were analyzed by one-way ANOVA followed by a Student–Newman–Keuls test. *P < 0.05. Ucr, urinary creatinine; Veh, vehicle. Scale bar = 40 µm.