Figure 4.

Podocyte-specific interleukin-1 receptor type 1 (IL-1R1) deletion promotes podocyte loss and apoptosis induced by nephrotoxic serum (NTS) or adriamycin (ADR) in mice. A: representative immunostaining for Wilms’ tumor 1 (WT1) and cleaved caspase-3 (CC3) in glomeruli from the different groups after NTS. B: quantitative determination of WT1 and cleaved caspase-3 in glomeruli from A (n = 3–6). C: representative immunostaining for WT1 and cleaved caspase-3 in glomeruli from the different groups after ADR. D: quantitative determination of WT1 and cleaved caspase-3 in glomeruli from C (n = 3–6). P values in B and D were analyzed by one-way ANOVA followed by a Student–Newman–Keuls test. *P < 0.05. Scale bar = 40 µm. Veh, vehicle.