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Pathway involving IL-6 and insulin resistance. Elevated levels of IL-6 bind to its receptor IL-6R, leading to JAK-STAT pathway involving STAT3 dimerization and enhanced levels of SOCS-3, which tag the IRS-1 protein for ubiquitin-based degradation. This finally results in failure of transport of GLUT-4 carrying vesicles to plasma membrane of cells and suspension of uptake of glucose into cells, leading to high glucose levels in blood
