Fig. 8.

Isoform distribution and viral load. The correlation between viral load in each clinical sample and count proportion for isoforms that belong to DAS genes (blue) and for isoforms of non-DAS genes (red) is shown. For each isoform, the proportion of its counts out of the total number of isoform counts of its corresponding gene was calculated in each sample, and a Kendall correlation test between these values and the fractions of SARS-COV2 RNA was performed. The y-axis corresponds to the −log₁₀ of the p-value. The red dashed line corresponds to a p-value of 0.05. The correlation between the raw proportions of differentially-spliced isoforms and suggest that the severity of viral infection as reflected in viral load may be a factor in determining the distribution of patterns of alternative splicing. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)