Appendix 4.

Drug-related problems identified in chronic disease patients (N total = 427 DRPs) and univariate analysis in DRPs predict all of the other DRPs ( DRPs VS Non-DRPs )

	Drug-related problems (DRPs)	n (%)	Odds ratio	95%CI	P-value
1.	Changes of drug packaging or drug brands	94 (18.84)	2.31	1.43-3.76	0.0002
2.	Leftover medications more than 2 weeks	92 (18.44)	3.86	2.34-6.42	< 0.001
3.	Non-adherence	87 (17.43)	2.39	1.46-3.95	0.0002
4.	Having conditions or diseases requiring additional medications	34 (6.81)	0.83	0.69-1.01	0.058
5.	Adverse drug reactions	26 (5.21)	3.61	1.41-10.33	0.0026
6.	Having an emergency requiring treatment at a hospital before next appointment date	25 (5.01)	0.87	0.72- 1.04	0.142
7.	Lack of knowledge about the purpose, administration and storage of drugs	23 (4.61)	0.88	0.73- 1.05	0.169
8.	The quantity of drugs received is not sufficient to cover needs until next follow up	12 (2.40)	0.92	0.77- 1.10	0.389
9.	Having abnormal symptoms due to a lack of drugs	8 (1.60)	0.94	0.78-1.12	0.499
10	The patient did not receive the drug.	7 (1.40)	0.94	0.79 - 1.12	0.528
11.	Incorrect use of specialized drug administration devices or techniques (e.g. inhalers, injected medications)	6 (1.20)	0.94	0.79- 1.13	0.558
12.	Experienced unexpected drug interactions with other drugs, food or supplements	5 (1.00)	0.95	0.79- 1.13	0.589
13.	Patients do not understand the meaning of the printed materials included with drugs	4 (0.80)	0.95	0.81-1.14	0.621
14.	Changes or errors in drug dosage (e.g. dispensing error, brand change/shortage)	4 (0.80)	0.95	0.80- 1.14	0.621