Fig. 1.

Genotype–phenotype analysis of FUS/TBK1 double-mutant patients. A, B Pedigrees of the two FALS families with co-occurrence of mutations in TBK1 and FUS. Arrows indicate index patients. Age at onset (in years) and duration of disease (in months) are indicated next to or below each patient. C, D Bar graphs showing age of onset and disease duration (time since disease onset until death or tracheostomy) of FUS/TBK1 double-mutant ALS patients (consisting of patients A II.4, B II.3, B II.5, and B III.2 in Table 2) compared to a large international cohort of FUS-ALS patients