Table 2.
Logistic regression model showing the association of different variables with progression
| Variable | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| Factors selected | ||||
| Age, years | ||||
| < 65 | 1 (reference) | 1 (reference) | ||
| ≥ 65 | 4.724 (1.727–12.917) | 0.002* | 7.004 (1.783–27.505) | 0.005* |
| Ln (proteinuria, g/24 h) | 4.408 (1.093–17.774) | 0.037* | 5.939 (1.055–33.436) | 0.043* |
| Ln (sPLA2R-Ab, U/mL) | 1.002 (1.001–1.004) | 0.001* | 2.150 (1.293–3.577) | 0.003* |
| Ln (Uα1m/Cr, mg/mg) | 1.002 (1.001–1.004) | 0.001* | 2.808 (1.035–7.619) | 0.043* |
| Factors not selected | ||||
| Sex | ||||
| Male | 1 (reference) | |||
| Female | 1.745 (0.620–4.917) | 0.292 | ||
| Hypertension | ||||
| Without | 1 (reference) | |||
| With | 1.150 (0.444–2.976) | 0.773 | ||
| Diabetes | ||||
| Without | 1 (reference) | |||
| With | 2.118 (0.584–0.768) | 0.254 | ||
| Albumin, g/L | 0.826 (0.729–0.937) | 0.003* | ||
| Serum creatinine, μmol/L | 1.015 (0.996–1.034) | 0.131 | ||
| Serum IgG, mg/dL | 0.999 (0.996–1.001) | 0.232 | ||
| CKD stage | ||||
| CKD 1 | 1.0 (reference) | |||
| CKD 2/3 | 4.121 (1.533–11.080) | 0.005* | ||
| Ln (UIgG/Cr, mg/g) | 1.022 (1.002–1.043) | 0.032* | ||
| Ln (UTf/Cr, mg/g) | 2.850 (1.358–5.983) | 0.006* | ||
| Ln (NAG/Cr, U/g) | 1.041 (1.014–1.068) | 0.002* | ||
| MN stage | ||||
| Stage I | 1.0 (reference) | |||
| Stage II/III | 1.167 (0.447–3.042) | 0.753 | ||
| Acute tubular injury | ||||
| Without | 1.0 (reference) | |||
| With | 1.250 (0.404–3.867) | 0.699 | ||
| Focal segmental glomerular sclerosis | ||||
| Without | 1.0 (reference) | |||
| With | 1.562 (0.496–4.920) | 0.446 | ||
| Tubular atrophy | ||||
| Stage 0 | 1.0 (reference) | |||
| Stage 1 | 1.851 (0.578–5.925) | 0.300 | ||
| Interstitial fibrosis | ||||
| Stage 0 | 1.0 (reference) | |||
| Stage 1 | 1.696 (0.535–5.383) | 0.370 | ||
| Vascular hyalinosis | ||||
| Without | 1.0 (reference) | |||
| With | 1.202 (0.465–3.112) | 0.704 | ||
| C3 deposits | ||||
| Without | 1.0 (reference) | |||
| With | 2.054 (0.434–9.716) | 0.364 | ||
C3 complement 3, CKD chronic kidney disease, Ln natural logarithm, MN membranous nephropathy, NAG N-acetyl-β-d-glucosaminidase, OR odds ratio, sPLA2R-Ab serum phospholipase A2 receptor antibody, Uα1m urinary α1-microglobulin, UTf urinary transferrin
* p < 0.05