Table 2.

Hazard ratios of psychiatric disorders among children of mothers with continued use of specific types of antipsychotic, compared with mothers with discontinued use.

Antidepressant use during pregnancya	Cases	Total number	Person years	Crude hazard ratio	Adjusted hazard ratio (95% CI)b
Prescription of N05AA Phenothiazines with aliphatic side-chain antipsychotic:
Discontinuation group	135	1005	11,044	1	1 (ref)
Continuation group	15	107	1197	1.04	0.89 (0.50, 1.57)
Prescription of N05AB Phenothiazines with piperazine structure antipsychotic:
Discontinuation group	91	636	7839	1	1 (ref)
Continuation group	22	171	1662	1.37	0.92 (0.54, 1.57)
Prescription of N05AF Thioxanthene derivatives antipsychotic:
Discontinuation group	405	3720	31,591	1	1 (ref)
Continuation group	97	599	5251	1.40	1.28 (1.01, 1.62)
Prescription of N05AH Diazepines, oxazepines, thiazepines and oxepines antipsychotic:
Discontinuation group	129	2085	11,145	1	1 (ref)
Continuation group	59	826	4578	1.09	1.01 (0.72, 1.41)
Prescription of N05AX Other antipsychotics:
Discontinuation group	112	1169	7631	1	1 (ref)
Continuation group	19	238	1450	0.91	0.83 (0.50, 1.40)

^aNumbers for N05AC Phenothiazines with piperidine structure, N05AD Butyrophenone derivatives, N05AE Indole derivatives, N05AG Diphenylbutylpiperidine derivatives and N05AL Benzamides were too small to meet Danish regulations for reporting.

^bAdjusted for maternal age at delivery, primiparity, in- and outpatient psychiatric treatment from 2 years before pregnancy until delivery, prescriptions for other psychotropic drugs during pregnancy, prescriptions for antiepileptic drugs during pregnancy, number of non-psychiatric hospital visits during pregnancy, smoking during pregnancy, marital status, highest education, calendar year of delivery and paternal psychiatric history at time of delivery.