Table 3.
Hazard ratios for types of psychiatric disorders among children of mothers with continued antipsychotic use during pregnancy, compared with mothers with discontinued antipsychotic use.
| Antipsychotic use during pregnancya | Cases | Total number | Person years | Crude hazard ratio | Adjusted hazard ratio (95% CI)b |
|---|---|---|---|---|---|
| Autism spectrum disorder | |||||
| Antipsychotic discontinuation group | 114 | 6976 | 60,436 | 1 (ref) | 1 (ref) |
| Antipsychotic continuation group | 26 | 2035 | 16,141 | 0.92 | 0.83 (0.53, 1.29) |
| Neurotic, stress related and somatoform disorders | |||||
| Antipsychotic discontinuation group | 182 | 6976 | 60,053 | 1 (ref) | 1 (ref) |
| Antipsychotic continuation group | 61 | 2035 | 15,832 | 1.43 | 1.08 (0.79, 1.50) |
| Attention deficit/hyperactivity disorders | |||||
| Antipsychotic discontinuation group | 216 | 6976 | 60,086 | 1 (ref) | 1 (ref) |
| Antipsychotic continuation group | 51 | 2035 | 16,035 | 0.95 | 0.85 (0.62, 1.15) |
| Emotional other than attention deficit/hyperactivity disorders | |||||
| Antipsychotic discontinuation group | 183 | 6976 | 59,953 | 1 (ref) | 1 (ref) |
| Antipsychotic continuation group | 80 | 2035 | 15,776 | 1.71 | 1.32 (0.99, 1.76) |
aNote that these outcomes are not mutually exclusive as a child may receive a diagnoses within more than one disorder category.
bAdjusted for maternal age at delivery, primiparity, in- and outpatient psychiatric treatment from 2 years before pregnancy until delivery, prescriptions for other psychotropic drugs during pregnancy, number of non-psychiatric hospital visits during pregnancy, smoking during pregnancy, marital status, highest education, calendar year of delivery and paternal psychiatric history at time of delivery.