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. 2022 Jan 21;12:1142. doi: 10.1038/s41598-022-05219-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Biomarkers kinetic. Time course of: (A) radical oxygen species (ROS) production rate (μmol·min⁻¹) and (B) total antioxidant capacity (TAC—mM) in saliva assessed by EPR; (C) uric acid (mM); (D) 8-isoprostane (8-iso-PGF2α, pg mg⁻¹ creatinine); (E) nitric oxide metabolites (NOx, μM), (F) creatinine (g L⁻¹), (G) neopterin (μmol mol⁻¹creatinine), concentrations detected in urine. In (H) cortisol levels (ng/mL) measured in saliva. *p < 0.05, **p < 0.01, ***p < 0.001 significantly different. Figure created with: GraphPad Prism, GraphPad Software inc. California, USA, version 9.0.1, https://www.graphpad.com/.