Table 2.

Comparison of results of SA of ODE model (simulations with input signals (A) 10 $\mathrm{\mu }$M TNF and 4 Gy IR and (B) 10 $\mathrm{\mu }$M TNF and 10 Gy IR) and analysis of Petri net model based on the selected parameters with the most significant impact on the modeled system.

A*
Biological process	Sensitivity analysis of ODE-based model		Significance analysis of Petri net-based model
	Parameter no.	Pos. in ranking	Transition no.	frequency trans/t-inv (%)
IR dependent DSB formation	73	1	t1	77.26
Degradation of ATMn/ATMpn/ATMan	86	2	t44/53/56	0.74
Degradation of Mdm2 mRNA	24	3	t19	2.03
Translation of Mdm2	42	4	t31	28.65
Degradation of ATM mRNA	85	5	t45	0.74
Transcription of ATM	97	6	t42	77.26
Transcription of Mdm2	39	7	t17	30.68
Translation of ATM	95	8	t43	76.52
Degradation of Mdm2p induced by Chk2p	27	9	t29	3.32
DNA damage repair induced by p53	80	10	t0	1.84
B*
Translation of Mdm2	42	1	t31	28.65
Transcription of Mdm2	39	2	t17	30.68
Degradation of Mdm2 mRNA	24	3	t19	2.03
DNA damage repair induced by p53	80	4	t0	1.84
Degradation of Mdm2p induced by Chk2p	27	5	t29	3.32
IR dependent DSB formation	73	6	t1	77.26
Ttranslation of Wip1	11	7	t32	21.44
Degradation of Wip1 mRNA	10	8	t34	2.40
Transcription of Wip1	11	9	t110	28.65
Degradation of Mdm2p	26	10	t99	2.03

${}^{\ast }$Transitions with significance above 20% are marked in bold font. It can be noticed that 50% of the results are common for ODE and Petri net models analyses, when comparing the significant reactions from the Petri net model to the significant parameters from the ODE model.