Table 4:

Treatment-Emergent Adverse Events^a Based on the Pediatric Adverse Events Rating Scale

Adverse event question	Micronutrient N (%)	Placebo N (%)	Total N (%)
Irritability	1 (1.6)	1 (3.0)	2 (2.1)
Angry or hostile	3 (4.7)	1 (3.0)	4 (4.1)
Sad or low mood	2 (3.1)	0 (0.0)	2 (2.1)
Lack of interest	2 (3.1)	0 (0.0)	2 (2.1)
Mood swings	2 (3.1)	1 (3.0)	3 (3.1)
Anxious, tense or uptight	3 (4.7)	1 (3.0)	4 (4.1)
Lack of self-control/impulsive	3 (4.7)	2 (6.1)	5 (5.2)
Trouble paying attention or concentrating	2 (3.1)	0 (0.0)	2 (2.1)
Racing thoughts	1 (1.6)	1 (3.0)	2 (2.1)
Can't sit or stand still	3 (4.7)	1 (3.0)	4 (4.1)
Tired/fatigued	2 (3.1)	1 (3.0)	3 (3.1)
Trouble falling asleep	4 (6.3)	1 (3.0)	5 (5.2)
Tried to hurt him/herself	1 (1.6)	0 (0.0)	1 (1.0)
Hurt someone or something	1 (1.6)	1 (3.0)	2 (2.1)
Less hungry	4 (6.3)	1 (3.0)	5 (5.2)
Lost weight	0 (0.0)	1 (3.0)	1 (1.0)
Dry mouth	1 (1.6)	0 (0.0)	1 (1.0)
Gained weight	0 (0.0)	1 (3.0)	1 (1.0)
Muscle shaking, stiffness or cramps	0 (0.0)	1 (3.0)	1 (1.0)
Tics	0 (0.0)	1 (3.0)	1 (1.0)
Unusually good mood or super happy	1 (1.6)	1 (3.0)	2 (2.1)
Skin rash or irritation	1 (1.6)	0 (0.0)	1 (1.0)
Heart racing or skipping beats	0 (0.0)	1 (3.0)	1 (1.0)
GI Symptomsb	17 (26.6)c	8 (24.2)c	25 (25.8)
Stomach ache or cramps	7 (10.9)	6 (18.2)	13 (13.4)
Nausea/sick to stomach	3 (4.7)	1 (3.0)	4 (4.1)
Throwing up/vomiting	4 (6.3)	0 (0.0)	4 (4.1)
Diarrhea	7 (10.9)	1 (3.0)	8 (8.2)
Headache	1 (1.6)	2 (6.1)	3 (3.1)
Other	5 (7.8)	5 (15.2)	10 (10.3)

Note:

^aAEs rated as “possibly,” “probably,” or “likely” attributable to the intervention. Number and percentages refer to participants having the AE, not number of AEs

^bGI = Gastrointestinal; symptoms are a combination of discrete participants experiencing stomach ache or cramps, nausea/sick to stomach, throwing up/vomiting, and diarrhea

^cp = 0.80