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. 2022 Jan 21;13:432. doi: 10.1038/s41467-022-28078-1

Fig. 3. Remodeling of the Mtb 70SIC upon binding MtbEttA in the Pre_R1 state.

Fig. 3

a Models of the 70SIC-MtbEttA complex in the Pre_R0 (transparent) and Pre_R1 (solid color) states are superimposed based on the 23S rRNA. 50S, 30S, and tRNA for the Pre_R0 state are shaded in the background. MtbEttA, bL31, and uL5 are shown as models. b A zoom-in view at the split interface. Directions of movements for MtbEttA, 30S, bL31, and uL5 are indicated by black arrows. c Rearranged 50S-30S interface in the Pre_R1 state. Direction and position of the view are indicated by the eye cartoon and a dashed vertical line in (a). d A close-up view of the rearranged base stacking in the Pre_R1 state is shown, with arrows indicating movements of corresponding nucleotides from the Pre_R0 state (transparent).