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. 2022 Jan 21;13:432. doi: 10.1038/s41467-022-28078-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Overall structural comparison of MtbEttA in the pre-hydrolysis and transition states. Models are aligned based on NBD1. NBD1 and arm domain are colored in light gray. PtIM and NBD2 are colored from light pink to dark purple for different states. The close-up views of the tip of PtIM and the base of PtIM α1 are shown in (b and c), respectively. Residue H214 of the H-switch in NBD1 is colored in pale green. d Top view of MtbEttA from the direction of the eye cartoon in a. Focused views of NBD2 and the Q-loop in NBD2 are shown in (e and f), respectively. The curved arrow indicates the rotation of NBD2 in (e), and Residue Q391 is colored in dodger blue in (f). Nucleotides are shown as stick models in (c, e, and f).