Fig. 5.
Bioinformatics analysis of MHC class I related genes from GEO. A Visualization of MHC class I+ related genes expression using microarray data from GSE 11089. Color was assigned to each range based on the log2 fold change value. Up-regulated genes belong in − log10 p-value > 1.3, log2 fold change > 1, while down-regulated genes belong in − log10 p-value > 1.3, log2 fold change > − 1. B From comparison MHC class I- versus MHC class I+ in keratinocyte stem cell, the up-regulated genes were shown in red color and down-regulated genes in green color. C Bubble chart displayed the GO biological process related to up-regulated and down-regulated genes of MHC class I+ group. Total 20 of biological process were listed based on − log10 p-value. Bubble size is the count of overlap genes from DEGs. D A total of 16 genes involved in inflammation and WNT signaling pathway were selected based on Gene-Set Enrichment Analysis (GSEA) information