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. 2022 Jan 21;7:7. doi: 10.1038/s41541-022-00436-6

Fig. 5. Nasal swab viral loads in COH04S1-vaccinated NHP after SARS-CoV-2 challenge.

Fig. 5

SARS-CoV-2 genomic RNA (gRNA; a–c) and subgenomic RNA (sgRNA; d–f) copies and TCID50 infectious virus titers (g–i) were measured at the indicated days post challenge in nasal swab samples of COH04S1-2D and COH04S1-1D-vaccinated NHP and mock-vaccinated and sMVA vector control animals. Lines represent geometric means + geometric s.d. Dotted lines represent lower limit of detection. Two-way ANOVA followed by Sidak’s multiple comparison test was used. Panels c, f, and i show viral loads by area under the curve (AUC). Violin plots show value ranges with median values (dashed line) and quartiles (dotted line). AUC = 0 was indicated as 1. One-way ANOVA followed by Tukey’s multiple comparison test was used. *0.05 < p < 0.01, **0.01 < p < 0.001, ***0.001 < p < 0.0001, ****p < 0.0001.