Table 1.
Characteristics of 103 patients with AE-IPF.
| Overall (n = 103) | Survivors (n = 55) | Non-survivors (n = 48) | P value | |
|---|---|---|---|---|
| Male sex n (%) | 88 (85.4%) | 45(81.8%) | 43(89.6%) | 0.4 |
| Age median (range) | 73.7 ± 6.9 | 73.4 ± 7.2 | 74.1 ± 6.6 | 0.76 |
| Smoking history | ||||
| Never/former/current | 19/81/3 | 10/44/1 | 9/37/2 | 0.98 |
| Pack-years (mean ± SD) | 57.9 ± 31.2 | 58.3 ± 29.3 | 56.4 ± 34.3 | 0.56 |
| %FVC | 71.0 ± 71.8 | 72.9 ± 21.0 | 68.6 ± 19.1 | 0.44 |
| %DLco | 35.5 ± 30.4 | 37.2 ± 29.6 | 33.6 ± 31.4 | 0.57 |
| GAP score | 2.7 ± 2.2 | 2.8 ± 2.3 | 2.6 ± 2.2 | 0.68 |
| Laboratory and radiological findings at the onset of AE-IPF | ||||
| PaO2/FiO2 ratio | 252.2 ± 85.6 | 283.3 ± 79.3 | 217.4 ± 79.3 | < 0.001* |
| KL-6 (U/ml) | 1535.3 ± 1856.8 | 1291.4 ± 875.2 | 1748.2 ± 2397.2 | 0.58 |
| SP-D (ng/ml) | 438.6 ± 356.6 | 395.9 ± 321.9 | 487.6 ± 390.3 | 0.22 |
| SP-A (ng/ml) | 103.0 ± 58.5 | 101.9 ± 60.6 | 104.4 ± 56.5 | 0.98 |
| LDH (U/l) | 373.9 ± 186.1 | 329.1 ± 68.7 | 424.3 ± 253.3 | 0.007* |
| CRP (mg/dl) | 8.0 ± 6.4 | 6.2 ± 5.5 | 10.0 ± 6.9 | 0.002* |
| Diffuse HRCT pattern, n (%) | 73 (70.9) | 30 (54.5) | 43 (89.6) | < 0.001* |
%FVC, Forced vital capacity, % of predicted value; %DLco, Carbon monoxide diffusing capacity -% of predicted value; GAP score. Gender-Age-Physiology score; KL-6, Krebs von der Lungen-6; SP-D, surfactant protein D; SP-A, surfactant protein A; LDH, lactate dehydrogenase; CRP, C-reactive protein; HRCT, high-resolution computed tomography; CS, corticosteroid, PMX-DHP, Polymyxin B-immobilized fiber column-direct hemoperfusion; rhTM, recombinant human thrombomodulin.
*P < 0.05.